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Prevention of Early Childhood Caries Using Fluoride Varnish
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Principal Investigator: Pamela Den Besten, DDS, MS

Investigators:
Charles Hoover, PhD
Ling Zhan, DDS

Specific Aim:

To determine the reduction in mutans Streptococci colony forming units (CFU) following a single application of 1% Povidone iodine, in children under five years of age, with early childhood caries. Either Povidone iodine (active treatment group), or deionized water (control group) will be applied following full-mouth dental rehabilitation under general anesthesia. Saliva will be collected, and both the total oral viable flora and MS (CFU per ml of saliva) will be measured prior to dental restoration and following Povidone iodine application (1hr, 3wks and 3 mo).

The goal of this project is to determine the effectiveness of Povidone iodine as a means of reducing bacteria that causes toot decay, including mutans Streptococci (MS), the oral cavity of children suffering from rampant caries.

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